Publications
For a comprehensive list of published work, refer to the PubMed link below:
Updated Publications
2025
Shikimate Kinase-Like 1 Participates in an Ancient and Conserved Role Contributing to Chloroplast Biogenesis in Land Plants. Kanaris, M., Lee, J., Chang, B., Christendat D. Molecular Biology and Evolution. 2025 June; 42:6. https://doi.org/10.1093/molbev/msaf129.
2021
Elevated tyrosine results in the cytosolic retention of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase in Arabidopsis thaliana. Kanaris M, Poulin J, Shahinas D, Johnson D, Crowley VM, Fucile G, Provart N, Christendat D. Plant J. 2022 Feb;109(4):789-803. doi: 10.1111/tpj.15590. Epub 2021 Dec 5. PMID: 34797933.
2020
QuiC2 represents a functionally distinct class of dehydroshikimate dehydratases identified in Listeria species including Listeria monocytogenes. Xue K, Prezioso S, Christendat D. Environ Microbial. 2020 Mar;22(7):2680-2692. doi:10.1111/1462-2920.14987
Structural and biochemical analysis of Bacillus anthracis prephenate dehydrogenase reveals an unusual mode of inhibition by tyrosine via the ACT domain. Shabalin IG, Gritsunov A, Hou J, Sławek J, Miks CD, Cooper DR, Minor W, Christendat D. FEBS J. 2020 Jun;287(11):2235-2255. doi: 10.1111/febs.15150. PMID: 31750992; PMCID: PMC7239764.
2018
Structural and biochemical approaches uncover multiple evolutionary trajectories of plant quinate dehydrogenases. Gritsunov A, Peek J, Diaz Caballero J, Guttman D, Christendat D. Plant J. 2018 June 11.
Shikimate Induced Transcriptional Activation of Protocatechuate Biosynthesis Genes by QuiR, a LysR-Type Transcriptional Regulator, in Listeria monocytogenes. Prezioso SM, Xue K, Leung N, Gray-Owen SD, Christendat D. J Mol Biol. 2018 Apr 27;430(9):1265-1283.
2017
Structurally diverse dehydroshikimate dehydratase variants participate in microbial quinate catabolism.Peek J, Roman J, Moran GR, Christendat D. Mol Microbiol. 2017 Jan;103(1):39-54.
2015
The shikimate dehydrogenase family: functional diversity within a conserved structural and mechanistic framework. Peek J, Christendat D. Arch Biochem Biophys. 2015 Jan 15;566:85-99.
2014
Isolation and molecular characterization of the shikimate dehydrogenase domain from the Toxoplasma gondii AROM complex. Peek J, Castiglione G, Shi T, Christendat D.Mol. Biochem. Parasitol. 2014 Mar-Apr;194(1-2):16-9
Identification of Novel Polyphenolic Inhibitors of Shikimate Dehydrogenase (AroE). Peek J, Shi T, Christendat D.J Biomol Screen 2014 Mar;19(7):1090-1098
2013
Crystal structure and biochemical analyses reveal that the Arabidopsis triphosphate tunnel metalloenzyme AtTTM3 is a tripolyphosphatase involved in root development.Moeder W, Garcia-Petit C, Ung H, Fucile G, Samuel MA, Christendat D, Yoshioka K.Plant J. 2013 Nov;76(4):615-26
Sequencing and annotation of the Ophiostoma ulmi genome.Khoshraftar S, Hung S, Khan S, Gong Y, Tyagi V, Parkinson J, Sain M, Moses AM, Christendat D.BMC Genomics 2013;14:162
Insights into the function of RifI2: structural and biochemical investigation of a new shikimate dehydrogenase family protein.Peek J, Garcia C, Lee J, Christendat D.Biochim. Biophys. Acta 2013 Feb;1834(2):516-23
2011
Structural and mechanistic analysis of a novel class of shikimate dehydrogenases: evidence for a conserved catalytic mechanism in the shikimate dehydrogenase family.Peek J, Lee J, Hu S, Senisterra G, Christendat D.Biochemistry 2011 Oct;50(40):8616-27
Structural and biochemical investigation of two Arabidopsis shikimate kinases: the heat-inducible isoform is thermostable.Fucile G, Garcia C, Carlsson J, Sunnerhagen M, Christendat D.Protein Sci. 2011 Jul;20(7):1125-36
ePlant and the 3D data display initiative: integrative systems biology on the world wide web.Fucile G, Di Biase D, Nahal H, La G, Khodabandeh S, Chen Y, Easley K, Christendat D, Kelley L, Provart NJ.PLoS ONE 2011;6(1):e15237
2009
The crystal structure of Aquifex aeolicus prephenate dehydrogenase reveals the mode of tyrosine inhibition.Sun W, Shahinas D, Bonvin J, Hou W, Kimber MS, Turnbull J, Christendat D.J. Biol. Chem. 2009 May;284(19):13223-32
2008
Evolutionary diversification of plant shikimate kinase gene duplicates.Fucile G, Falconer S, Christendat D.PLoS Genet. 2008 Dec;4(12):e1000292
A phylogenomic analysis of the shikimate dehydrogenases reveals broadscale functional diversification and identifies one functionally distinct subclass.Singh S, Stavrinides J, Christendat D, Guttman DS.Mol. Biol. Evol. 2008 Oct;25(10):2221-32
dentification of a functionally essential amino acid for Arabidopsis cyclic nucleotide gated ion channels using the chimeric AtCNGC11/12 gene.Baxter J, Moeder W, Urquhart W, Shahinas D, Chin K, Christendat D, Kang HG, Angelova M, Kato N, Yoshioka K.Plant J. 2008 Nov;56(3):457-69
Structural insight on the mechanism of regulation of the MarR family of proteins: high-resolution crystal structure of a transcriptional repressor from Methanobacterium thermoautotrophicum.Saridakis V, Shahinas D, Xu X, Christendat D.J. Mol. Biol. 2008 Mar;377(3):655-67
2006
Structure of Arabidopsis dehydroquinate dehydratase-shikimate dehydrogenase and implications for metabolic channeling in the shikimate pathway.Singh SA, Christendat D.Biochemistry 2006 Jun;45(25):7787-96
Biochemical characterization of prephenate dehydrogenase from the hyperthermophilic bacterium Aquifex aeolicus.Bonvin J, Aponte RA, Marcantonio M, Singh S, Christendat D, Turnbull JL.Protein Sci. 2006 Jun;15(6):1417-32
Crystal structure of prephenate dehydrogenase from Aquifex aeolicus. Insights into the catalytic mechanism.Sun W, Singh S, Zhang R, Turnbull JL, Christendat D.J. Biol. Chem. 2006 May;281(18):12919-28
2005
The crystal structure of a novel SAM-dependent methyltransferase PH1915 from Pyrococcus horikoshii.Sun W, Xu X, Pavlova M, Edwards AM, Joachimiak A, Savchenko A, Christendat D.Protein Sci. 2005 Dec;14(12):3121-8
Crystal structure of a novel shikimate dehydrogenase from Haemophilus influenzae.Singh S, Korolev S, Koroleva O, Zarembinski T, Collart F, Joachimiak A, Christendat D.J. Biol. Chem. 2005 Apr;280(17):17101-8
2004
Crystal structure of the hypothetical protein TA1238 from Thermoplasma acidophilum: a new type of helical super-bundle.Sanishvili R, Pennycooke M, Gu J, Xu X, Joachimiak A, Edwards AM, Christendat D.J. Struct. Funct. Genomics 2004;5(4):231-40
The structural basis for methylmalonic aciduria. The crystal structure of archaeal ATP:cobalamin adenosyltransferase.Saridakis V, Yakunin A, Xu X, Anandakumar P, Pennycooke M, Gu J, Cheung F, Lew JM, Sanishvili R, Joachimiak A, Arrowsmith CH, Christendat D, Edwards AM.J. Biol. Chem. 2004 May;279(22):23646-53
Crystal structure of chorismate synthase from Aquifex aeolicus reveals a novel beta alpha beta sandwich topology.Viola CM, Saridakis V, Christendat D.Proteins 2004 Jan;54(1):166-9
Structure- and function-based characterization of a new phosphoglycolate phosphatase from Thermoplasma acidophilum.Kim Y, Yakunin AF, Kuznetsova E, Xu X, Pennycooke M, Gu J, Cheung F, Proudfoot M, Arrowsmith CH, Joachimiak A, Edwards AM, Christendat D.J. Biol. Chem. 2004 Jan;279(1):517-26
2003
Crystal structures of MTH1187 and its yeast ortholog YBL001c.Tao X, Khayat R, Christendat D, Savchenko A, Xu X, Goldsmith-Fischman S, Honig B, Edwards A, Arrowsmith CH, Tong L.Proteins 2003 Aug;52(3):478-80
Data mining crystallization databases: knowledge-based approaches to optimize protein crystal screens.Kimber MS, Vallee F, Houston S, Necakov A, Skarina T, Evdokimova E, Beasley S, Christendat D, Savchenko A, Arrowsmith CH, Vedadi M, Gerstein M, Edwards AM.Proteins 2003 Jun;51(4):562-8
Structural proteomics: toward high-throughput structural biology as a tool in functional genomics.Yee A, Pardee K, Christendat D, Savchenko A, Edwards AM, Arrowsmith CH.Acc. Chem. Res. 2003 Mar;36(3):183-9
Deep trefoil knot implicated in RNA binding found in an archaebacterial protein.Zarembinski TI, Kim Y, Peterson K, Christendat D, Dharamsi A, Arrowsmith CH, Edwards AM, Joachimiak A.Proteins 2003 Feb;50(2):177-83
2002
The crystal structure of MT0146/CbiT suggests that the putative precorrin-8w decarboxylase is a methyltransferase.Keller JP, Smith PM, Benach J, Christendat D, deTitta GT, Hunt JF.Structure 2002 Nov;10(11):1475-87
Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase.Batra R, Christendat D, Edwards A, Arrowsmith C, Tong L.Proteins 2002 Nov;49(2):285-8
The crystal structure of hypothetical protein MTH1491 from Methanobacterium thermoautotrophicum.Christendat D, Saridakis V, Kim Y, Kumar PA, Xu X, Semesi A, Joachimiak A, Arrowsmith CH, Edwards AM.Protein Sci. 2002 Jun;11(6):1409-14
Crystal structure of Methanobacterium thermoautotrophicum conserved protein MTH1020 reveals an NTN-hydrolase fold.Saridakis V, Christendat D, Thygesen A, Arrowsmith CH, Edwards AM, Pai EF.Proteins 2002 Jul;48(1):141-3